Eukaryotic DNA replication

DNA replication is an area of intense research effort which has recently yielded fascinating new insights into the phenomenon. In this book, leading researchers review this rapidly advancing field. The book begins with reviews of the molecular and genetic components of the replication machinery, and builds into a detailed picture of how the replication process is regulated within the cell cycle. Topics include the initiation of replication, origin recognition, the enzymology of the replication fork, the use of SV40 to identify key components of the replication machinery, and how replication is co-ordinated with other cell cycle events in Xenopus cell-free extracts and in budding and fission yeasts. Eukaryotic DNA Replication is a unique and very timely description of the latest research findings in this key subject area. It is essential reading for all researchers and advanced undergraduates interested in the topic.